A clue to diagnosis in a boy with short stature: Testicular enlargement.

Acquired hypothyroidism is one of the most common endocrine disorders in the childhood, but long-term problems are observed in rare untreated patients. Van Wyk-Grumbach syndrome which is one of these problems was described as juvenile hypothyroidism, delayed bone age and isosexual early puberty in 1960 for the first time (1). This condition is mostly manifested with ovarian cysts, early menstrual bleeding and galactorrhea in girls (1-3), while it is manifested with prominent penile enlargement and increased testicular size without increased testeosterone rarely in boys (4, 5). Complete recovery is provided by administering thyroid hormone in both genders (6). In this article, we present an 8 year 9 month-old male patient who presented with short stature in whom increased testicular size found on physical examination directed us to the diagnosis.